Juvéderm
Allergan Aesthetics, an AbbVie company
cheeks, chin, temples, jawline, lips, perioral lines, nasolabial folds, infraorbital hollow
Juvéderm vs. Restylane
Last verified 7/30/2026
Restylane
Galderma / Q-Med AB
lips, perioral lines, nasolabial folds, cheeks, chin, temples, infraorbital hollow, dorsal hands
Quick comparison
| Attribute | Juvéderm | Restylane |
|---|---|---|
| Manufacturer | Allergan Aesthetics, an AbbVie company | Galderma / Q-Med AB |
| Base material | cross-linked hyaluronic acid gels | cross-linked hyaluronic acid gels |
| Intended areas | cheeks, chin, temples, jawline, lips, perioral lines, nasolabial folds, infraorbital hollow | lips, perioral lines, nasolabial folds, cheeks, chin, temples, infraorbital hollow, dorsal hands |
| Primary purpose | Product-specific facial augmentation or correction across cheeks, chin, temples, jawline, lips, perioral lines, folds, and infraorbital hollowing. | Product-specific augmentation or correction of lips, folds, cheeks, chin, temples, infraorbital hollowing, and dorsal hands. |
| Product behavior | Cross-linked hyaluronic acid gel adds physical volume; rheology, concentration, cross-linking, lidocaine content, approved plane, and intended area differ by product. | Cross-linked hyaluronic acid gel adds physical volume; formulation technology, gel properties, lidocaine content, intended tissue plane, and area differ by product. |
| Results timing | Immediate gel volume, followed by reassessment after injection-related swelling. | Immediate gel volume, with final assessment after early swelling settles. |
| Typical longevity | Varies by the specific Juvéderm product, treatment area, amount, and patient; family-wide duration claims are not used. | Varies by exact Restylane product, area, amount, and patient; no family-wide duration is assigned. |
| Downtime and swelling | Common and area dependent. | Common and area dependent. |
| Reversibility | The HA gel may often be reduced with off-label hyaluronidase, but response is product dependent and not guaranteed. | The HA gel may often be reduced with off-label hyaluronidase, with product-dependent and incomplete response possible. |
| Pricing basis | Usually per syringe or mL; the exact Juvéderm product and syringe volume must be retained. | Usually per syringe or mL; retain the exact product and syringe volume. |
| Regulatory status | Juvéderm devices are FDA-approved through product-specific PMAs and supplements; the brand family does not have one universal indication. | Restylane devices are FDA-approved through product-specific PMAs and supplements; each product retains its own indication. |
| Major limitations | Choosing by brand family rather than by the exact product and intended area can create an invalid comparison or mismatched outcome. | A family-level comparison can hide clinically important product and treatment-area differences. |
Manufacturer
- Juvéderm
- Allergan Aesthetics, an AbbVie company
- Restylane
- Galderma / Q-Med AB
Base material
- Juvéderm
- cross-linked hyaluronic acid gels
- Restylane
- cross-linked hyaluronic acid gels
Intended areas
- Juvéderm
- cheeks, chin, temples, jawline, lips, perioral lines, nasolabial folds, infraorbital hollow
- Restylane
- lips, perioral lines, nasolabial folds, cheeks, chin, temples, infraorbital hollow, dorsal hands
Primary purpose
- Juvéderm
- Product-specific facial augmentation or correction across cheeks, chin, temples, jawline, lips, perioral lines, folds, and infraorbital hollowing.
- Restylane
- Product-specific augmentation or correction of lips, folds, cheeks, chin, temples, infraorbital hollowing, and dorsal hands.
Product behavior
- Juvéderm
- Cross-linked hyaluronic acid gel adds physical volume; rheology, concentration, cross-linking, lidocaine content, approved plane, and intended area differ by product.
- Restylane
- Cross-linked hyaluronic acid gel adds physical volume; formulation technology, gel properties, lidocaine content, intended tissue plane, and area differ by product.
Results timing
- Juvéderm
- Immediate gel volume, followed by reassessment after injection-related swelling.
- Restylane
- Immediate gel volume, with final assessment after early swelling settles.
Typical longevity
- Juvéderm
- Varies by the specific Juvéderm product, treatment area, amount, and patient; family-wide duration claims are not used.
- Restylane
- Varies by exact Restylane product, area, amount, and patient; no family-wide duration is assigned.
Downtime and swelling
- Juvéderm
- Common and area dependent.
- Restylane
- Common and area dependent.
Reversibility
- Juvéderm
- The HA gel may often be reduced with off-label hyaluronidase, but response is product dependent and not guaranteed.
- Restylane
- The HA gel may often be reduced with off-label hyaluronidase, with product-dependent and incomplete response possible.
Pricing basis
- Juvéderm
- Usually per syringe or mL; the exact Juvéderm product and syringe volume must be retained.
- Restylane
- Usually per syringe or mL; retain the exact product and syringe volume.
Regulatory status
- Juvéderm
- Juvéderm devices are FDA-approved through product-specific PMAs and supplements; the brand family does not have one universal indication.
- Restylane
- Restylane devices are FDA-approved through product-specific PMAs and supplements; each product retains its own indication.
Major limitations
- Juvéderm
- Choosing by brand family rather than by the exact product and intended area can create an invalid comparison or mismatched outcome.
- Restylane
- A family-level comparison can hide clinically important product and treatment-area differences.
Benefits and trade-offs
Juvéderm
- Product-dependent volume, projection, contour, and selected folds or hollows.
- The family name does not identify one formulation, one indication, one duration, or a neuromodulator effect.
- Choosing by brand family rather than by the exact product and intended area can create an invalid comparison or mismatched outcome.
Restylane
- Product-dependent volume, shape, projection, and correction of selected folds or hollows.
- The family is not one interchangeable formulation and does not relax muscles like a botulinum toxin.
- A family-level comparison can hide clinically important product and treatment-area differences.
Details
Open a section for more context. Sources appear beside the claims they support.
Range and formulation
| Attribute | Juvéderm | Restylane |
|---|---|---|
| How it works | Cross-linked hyaluronic acid gel adds physical volume; rheology, concentration, cross-linking, lidocaine content, approved plane, and intended area differ by product.
| Cross-linked hyaluronic acid gel adds physical volume; formulation technology, gel properties, lidocaine content, intended tissue plane, and area differ by product.
|
| Adds volume | Yes
| Yes
|
| What it primarily changes | Product-dependent volume, projection, contour, and selected folds or hollows.
| Product-dependent volume, shape, projection, and correction of selected folds or hollows.
|
| What it does not change | The family name does not identify one formulation, one indication, one duration, or a neuromodulator effect.
| The family is not one interchangeable formulation and does not relax muscles like a botulinum toxin.
|
How it works
- Juvéderm
- Cross-linked hyaluronic acid gel adds physical volume; rheology, concentration, cross-linking, lidocaine content, approved plane, and intended area differ by product.
- About the Juvéderm Collection · juvederm.com
- Restylane
- Cross-linked hyaluronic acid gel adds physical volume; formulation technology, gel properties, lidocaine content, intended tissue plane, and area differ by product.
- Restylane Science and Technology · restylaneusa.com
Adds volume
What it primarily changes
- Juvéderm
- Product-dependent volume, projection, contour, and selected folds or hollows.
- Juvéderm Collection: Treatment Areas · juvederm.com
- Restylane
- Product-dependent volume, shape, projection, and correction of selected folds or hollows.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
What it does not change
- Juvéderm
- The family name does not identify one formulation, one indication, one duration, or a neuromodulator effect.
- Juvéderm Collection: Treatment Areas · juvederm.com
- Restylane
- The family is not one interchangeable formulation and does not relax muscles like a botulinum toxin.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
Treatment experience
| Attribute | Juvéderm | Restylane |
|---|---|---|
| Downtime | Typically limited, but swelling, bruising, tenderness, redness, firmness, and lumps may occur. | Typically limited, but swelling, bruising, pain, tenderness, redness, and lumps can occur.
|
| Swelling | Common and area dependent. | Common and area dependent.
|
Downtime
- Juvéderm
- Typically limited, but swelling, bruising, tenderness, redness, firmness, and lumps may occur.
- Restylane
- Typically limited, but swelling, bruising, pain, tenderness, redness, and lumps can occur.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
Swelling
- Juvéderm
- Common and area dependent.
- Restylane
- Common and area dependent.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
Risks and limitations
| Attribute | Juvéderm | Restylane |
|---|---|---|
| Documented risks | Injection-site reactions, lumps or nodules, infection, inflammatory reactions, and rare intravascular injection with necrosis, vision loss, or stroke. | Injection-site reactions, nodules, infection, inflammatory reactions, and rare intravascular injection causing necrosis, vision loss, or stroke.
|
| Most likely disappointment | Choosing by brand family rather than by the exact product and intended area can create an invalid comparison or mismatched outcome.
| A family-level comparison can hide clinically important product and treatment-area differences.
|
| When this treatment may not be appropriate | When no product in the family is appropriate for the intended area or when filler contraindications or a non-volume problem applies. | When filler contraindications apply, the intended area lacks an appropriate product, or the concern is muscular, textural, or surgical rather than volumetric.
|
| Provider-dependent variables | Specific product, volume, injection plane, anatomy, technique, and management of vascular complications. | Specific product, total volume, anatomy, plane, needle or cannula, and complication preparedness.
|
Documented risks
- Juvéderm
- Injection-site reactions, lumps or nodules, infection, inflammatory reactions, and rare intravascular injection with necrosis, vision loss, or stroke.
- Restylane
- Injection-site reactions, nodules, infection, inflammatory reactions, and rare intravascular injection causing necrosis, vision loss, or stroke.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
Most likely disappointment
- Juvéderm
- Choosing by brand family rather than by the exact product and intended area can create an invalid comparison or mismatched outcome.
- Juvéderm Collection: Treatment Areas · juvederm.com
- Restylane
- A family-level comparison can hide clinically important product and treatment-area differences.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
When this treatment may not be appropriate
- Juvéderm
- When no product in the family is appropriate for the intended area or when filler contraindications or a non-volume problem applies.
- Restylane
- When filler contraindications apply, the intended area lacks an appropriate product, or the concern is muscular, textural, or surgical rather than volumetric.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
Provider-dependent variables
- Juvéderm
- Specific product, volume, injection plane, anatomy, technique, and management of vascular complications.
- Restylane
- Specific product, total volume, anatomy, plane, needle or cannula, and complication preparedness.
- Explore Restylane Products and Treatment Areas · restylaneusa.com
Evidence and regulatory status
| Attribute | Juvéderm | Restylane |
|---|---|---|
| United States regulatory status | Juvéderm devices are FDA-approved through product-specific PMAs and supplements; the brand family does not have one universal indication.
| Restylane devices are FDA-approved through product-specific PMAs and supplements; each product retains its own indication.
|
| Canadian regulatory status | Health Canada MDALL lists active Class III Juvéderm licences, including family and product-specific records; the exact licensed device and intended use must be checked.
| Health Canada MDALL lists active Class III Restylane licences, including product-specific records such as Restylane Kysse; exact licensed intended use must be checked.
|
| Evidence status | High for family composition and product-specific regulatory status; family-wide outcome and duration claims are intentionally avoided.
| High for family composition, safety framework, and product-specific regulation; no family-wide superiority or duration claim is made.
|
United States regulatory status
- Juvéderm
- Juvéderm devices are FDA-approved through product-specific PMAs and supplements; the brand family does not have one universal indication.
- FDA PMA P050047/S052 · accessdata.fda.gov
- Restylane
- Restylane devices are FDA-approved through product-specific PMAs and supplements; each product retains its own indication.
- FDA PMA P040024: Restylane · accessdata.fda.gov
Canadian regulatory status
- Juvéderm
- Health Canada MDALL lists active Class III Juvéderm licences, including family and product-specific records; the exact licensed device and intended use must be checked.
- Health Canada MDALL: Allergan Juvéderm licences · health-products.canada.ca
- Restylane
- Health Canada MDALL lists active Class III Restylane licences, including product-specific records such as Restylane Kysse; exact licensed intended use must be checked.
- Health Canada MDALL: Q-Med Restylane licences · health-products.canada.ca
Evidence status
- Juvéderm
- High for family composition and product-specific regulatory status; family-wide outcome and duration claims are intentionally avoided.
- FDA PMA P050047/S052 · accessdata.fda.gov
- Restylane
- High for family composition, safety framework, and product-specific regulation; no family-wide superiority or duration claim is made.
- FDA PMA P040024: Restylane · accessdata.fda.gov
SourcesShowHide
Sources are grouped by treatment so the support for each record stays visible.
Juvéderm
- About the Juvéderm Collection · juvederm.com
- FDA PMA P050047/S052 · accessdata.fda.gov · supports 2 fields
- Health Canada MDALL: Allergan Juvéderm licences · health-products.canada.ca
- Juvéderm Collection: Treatment Areas and Important Safety Information · juvederm.com · supports 22 fields
Restylane
- Explore Restylane Products and Treatment Areas · restylaneusa.com · supports 22 fields
- FDA PMA P040024: Restylane · accessdata.fda.gov, 2003-12-12 · supports 2 fields
- Health Canada MDALL: Q-Med Restylane licences · health-products.canada.ca
- Restylane Science and Technology · restylaneusa.com
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